Research Facilities Available at Lankenau Institute for Medical Research

frozen in a Retrieval a low- temperature, robotic repository system. The system’s no freeze -thaw capability the compounds’ quality This unique and powerful repository us offer custom drug screening sets ‘on the fly,’ in order to build structure -activity relationship models far more rapidly and cost-effectively than any other approach.


Why choose LIMR to advance your research?
We can customize your costs based on your specific needs.
Our location just over the county line from Philadelphia, in beautiful Montgomery County, PA, saves you additional costs over city-based facilities while still being convenient to major commuting roadways.
If your future plans are to focus on clinical studies, we have a robust clinical trials infrastructure in a hospital setting with full staffing support in place. LIMR's 500-square-foot cryogenics facility is available for archived storage of samples and cell lines.

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• Five (5) large, computer-monitored, liquid nitrogen-supplied freezers connected to a bulk liquid nitrogen tank that is remotely monitored by Airgas Inc.
• A manual fill station for liquid nitrogen on demand A state-of-the-art system controls and monitors environmental parameters (e.g., temperature, humidity, air flow, light cycles) in all rooms in real time, and maintains a continuous electronic log. Access to the facility and all rooms are controlled by both a card reader and a touch pad system.

Chemical Genomics Core
The LIMR Chemical Genomics Center (LCGC) provides specialized research services and resources to drug discovery scientists. Our mission is to accelerate translational research in cell signaling and new medicine discovery. We provide access to a large chemical library of over 250,000 small molecules suitable for high throughput screening (HTS) campaigns to discover new drug leads for the most challenging medical indications, including drug-resistant infections, metastatic cancer, and orphan diseases. The LCGC compound repositories include the following sets: 10

Orthogonal-Pooled Screening (OPS) Sets
All of our compounds are available as assay-ready drug screening plates in the OPS format, which guarantees 500% more efficient drug screening. We are the world's leader in this powerful approach that can detect hidden mechanism of synergistic drug action, including tripledrug combinations for infectious diseases and oncology indication. Chemical Genomics Core (cont'd) Automated Compound Repository LCGC's compound stock solutions are maintained frozen in a Nanotube Automated Retrieval System, a patented (US20100161119), state-of-the-art, low-temperature, robotic repository system. The system's no freeze-thaw cycling capability preserves the compounds' quality indefinitely. This unique and powerful repository system allows us to offer scientists custom drug screening sets 'on the fly,' in order to build structure-activity relationship models far more rapidly and cost-effectively than any other approach.

HTS Assay Development and Validation
Our chemical resources and lab automation infrastructure provide scientists with unparalleled speed and power to validate and execute successful new drug discovery campaigns at extremely affordable costs.

Human Antibody Technology
Monoclonal antibodies now comprise a major group of medicines, encompassing a multibillion-dollar market with diverse uses in research, diagnosis, prognosis and therapy. At present, such antibodies are generated from rodents and must be "humanized" for therapeutic use. Pure human antibodies are expected to offer many clinical benefits, but methods to generate them have been elusive.
LIMR's Center for Human Antibody Technology (CHAT) is a core facility that uses a powerful human antibody cloning platform technology developed by Scott Dessain, MD, PhD. CHAT uses this platform along with a state-of-theart, high throughput antibody production and screening facility to produce human antibodies for use in the treatment of infectious disease, cancer and neurological illnesses. CHAT is available as a regional resource to provide academic investigators the opportunity to create their own human antibody therapeutics. Planning to advance your research to clinic trials? LIMR has a robust clinical trials infrastructure in a hospital setting with full staffing support.
Overall, the unique hospital/clinical research center model, and integration of the expertise of both clinicians and investigators, can help advance your research initiatives to the clinic.