Program Director

Oxidative stress as a result of cerebrovascular injury, neuropathology and aging, is associated with various neurodegenerative disorders. There is increasing evidence that demonstrates the presence of lysosomal proteases and protease inhibitors in a number of these disorders associated with oxidative stress including aging and various types of neuronal injuries. Recent in vitro studies have demonstrated an alteration in the lysosomal proteases cathepsin B and cathepsin D in both cultured neurons and astrocytes undergoing oxidative stressed-induced apoptosis. In addition, in vitro studies indicate that cystatin C, an endogenous cysteine protease inhibitor, may have an important role in regulation of oxidative stressed-induced apoptosis in cultured cortical neurons. Thus, the objective of this project is to elucidate the potential relationship of cystatin C with the cysteine protease cathepsin B, and the aspartate protease cathepsin D in a model of oxidative stress-induced apoptosis. Thus, the proposed experiments examine and test the hypothesis that cystatin C activates cathepsin D induced apoptosis by suppressing cathepsin B following oxidative stress. This hypothesis will be tested in vitro with PC12 cell cultures exposed to hydrogen peroxide induced oxidative stress. Co-localization of cystatin C with cathepsins B and D, as well as quantitative changes in protein and messenger RNA and enzyme activity will be determined in differentiated PC12 cells undergoing apoptosis. In addition, knockdown of the cystatin C gene by RNA interference (RNAi) will be utilized to further characterize cystatin C's contribution to the neurodegenerative process following oxidative stress. The findings from this proposal will significantly increase the understanding of lysosomal protease involvement in neurodegeneration induced by oxidative stress, which will lead to the development of novel therapeutic treatments to retard neuronal death. Enhanced cystatin C and lysosomal protease expression following 6-hydroxydopamine exposure. pathway of cell death involving cathepsin D during tumor necrosis factor-a-induced apoptosis. D expression and activity is increased following 6-OHDA exposure and lysosomal cysteine protease suppression.

Do you have the skills and knowledge you need to confidently negotiate and draft IT agreements?
Join expert legal and IT specialists in this innovative and intensive course. You'll get a deep dive into the essential aspects of structuring, negotiating and drafting IT agreements, including: • Allocating liability and managing security, compliance and privacy issues • Crucial drafting tips and advanced negotiation strategies and tactics • Key IP issues that affect IT agreements • Critical cross-border considerations, emerging issues and technology trends • PLUS! Get personalized feedback, essential skills and practical strategies through learn-by-doing drafting and negotiating workshops Whether you're a lawyer in private practice or working within an organization in a legal or professional capacity, IT agreements will likely cross your desk. To avoid costly mistakes, you need to know how to anticipate problems, cover-off key points and adequately protect your client's interests.

Are you prepared?
In this intensive Osgoode Certificate, an expert faculty will provide you with the knowledge and skills you need to confidently and competently structure IT contracts and get practical tools to draft and negotiate contentious clauses. Over 4 Modules, you'll also learn about the critical business, tech and IP aspects underlying IT agreements, giving you a solid grounding in essential concepts.
You will also get the opportunity to reinforce your understanding of key concepts and apply what you've learned in small group drafting and negotiation workshops, where you will benefit from personalized feedback from expert facilitators.

Navigating Ethical Issues in IT Transactions
This module will teach you everything you need to know to handle thorny ethical issues, including how to address conflicts of interest and when the duty of good faith applies in negotiations.

Foundations of IT Agreements
Module 1 will provide you with the foundational knowledge you need to maximize your understanding and participation in the remainder of the certificate. You will learn the critical IP and technological aspects of IT contracts, systems and development, as well as the key cross-border issues to consider in IT agreements. The day will end with a primer on negotiation techniques.

Essential IP Elements & Concepts
• Types of IT that can be protected by trade secret, copyright, patents, and trademark laws • How is IP obtained, registered and enforced?
What is legally protectable confidential information?
• Independent creation as a defence to infringement and risks arising from joint ownership of IP

Take-Home Drafting Assignment: Distribution
The take-home drafting assignment will be distributed. This assignment is expected to take about 3-4 hours to complete and it will be due the week after Module 3.

MODULE 2 (IN-PERSON OR WEBCAST)
Wednesday, April 8, 2020 9:00 a.m. -5:00 p.m. EDT Privacy/Security; Software Development Module 2 will continue to examine the essential underlying concepts required for negotiating and drafting IT agreements. The discussion will drill down on strategies to allocate liability in an IT contract, and security and privacy issues. The focus will shift to examining specific types of IT agreements, including software development agreements. The day will conclude with an interactive demonstration to highlight best practices and tips for negotiating performance warranties and guarantee clauses.

Allocating Liability in the IT Contract
• Thinking through limits of liability, disclaimers, waivers and related clauses • Liability issues associated with privacy, security and confidentiality • Indemnities and how they are structured

Security Issues in IT Transactions
• Types of security risks: data integrity, transmission, access control, and more

Confidentiality Agreements and Escrow Agreements
This session will examine two key but under-appreciated contracts: Non-Disclosure Agreements (NDAs) and Source Code Escrow Agreements. Learn how to minimize the risks of disclosing and receiving confidential information, as well as the common problems and pitfalls with escrow agreements.

Development Agreements
• A developer's perspective: key assumptions and their implications • Failure rates and remedies, includes nonfinancial, non-performance and providing for escalation and dispute resolution procedures You will have an opportunity to observe and interact with a live negotiation from the perspective of both supplier and customer. The panel will examine various negotiation positions and provide guidance on the strategic use of language when drafting these important clauses.
Take-Home Drafting Assignment: Discussion/Q&A You will have the chance to clarify your outstanding questions on the drafting assignment. This assignment is expected to take about 3-4 hours to complete and it will be due the week after Module 3.

Fundamentals of Key IT Agreements
Module 3 will continue to examine specific types of IT agreements, including outsourcing, support and maintenance and software licensing agreements. Expert faculty will deliver our second interactive demonstration session, focusing on the negotiation of a License Agreement from the perspective of both supplier and customer. Observe senior practitioners negotiate the key elements of a License Agreement, and learn tools to effectively address issues including payment terms, scope, ownership of IP, strategies for negotiating value-adds, and governance provisions.

Drafting Assignment Deadline
The drafting assignment will be due the week after this Module 3.

MODULE 4 (IN-PERSON ONLY)
Thursday, May 21, 2020 9:00 a.m. In Module 4, you will have an opportunity to put into action what you have learned. The day will feature small groups, interactive workshops, plus a presentation on advanced negotiation techniques.

DRAFTING WORKSHOP & ASSIGMENT REVIEW: License Agreement
Get personalized feedback on your drafting skills and gain strategies, best practices and model drafting clauses from highly experienced faculty.

Instructional Session: Advanced Negotiation Techniques for IT Agreements
Building on the negotiation techniques primer delivered in Module 1, you will learn about using Game Theory and Behavioural Economics in your negotiations, as well as how to conduct a self-assessment of your negotiation skills.

NEGOTIATION WORKSHOP: Tying It All Together (Mock Negotiation)
In small groups, you will engage in a mock negotiation representing either the vendor or customer. You will receive individualized support and feedback from an expert facilitator and benefit from a master debrief and group discussion.

Registration Details
Fee per Delegate $2,995 plus HST Fees include attendance, program materials, lunch and break refreshments. Visit www.osgoodepd.ca/financial-assistance for details about financial assistance.

Program Changes
We will make every effort to present the program as advertised, but it may be necessary to change the date, location, speakers or content with little or no notice. In the event of program cancellation, York University's and Osgoode Hall Law School's liability is limited to reimbursement of paid fees.